Daichi Shonai
Unbiased Spatial Mapping of Neurodegenerative Proteome in Parkinson's Disease
Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopaminergic neurons, leading to motor and cognitive issues. The exact causes of PD are still unknown, but recent research suggests that protein trafficking disruptions might be key. This study investigates protein localization in dopaminergic neurons to understand its impact on PD’s progression. Using advanced proteomics methods, like iLOPIT-DC and iBioID, the aim is to map the proteomic landscape within living systems. Early results indicate altered protein localization in PD models, which could redefine our understanding of PD’s molecular basis. The study also hopes to identify PD biomarkers and new treatments, aligning with the PhRMA Foundation’s programs. This research offers a chance for the PhRMA Foundation’s Predoctoral Fellowship in Drug Discovery to support a transformative exploration of PD’s origins.
Receiving the PhRMA Foundation predoctoral fellowship is an incredible honor. This fellowship award propels me toward advancing scientific knowledge, translating discoveries into therapies, and making a meaningful impact in cancer research.
