Daichi Shonai

Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of nerve cells that produce dopamine, a chemical that helps these cells communicate with one another. This leads to movement issues such as tremors, rigidity, and stiffness. The reasons behind the selective loss of these cells remain unclear. My research focuses on uncovering the early molecular changes that occur within these cells, particularly disruptions in the transport of proteins, which are essential for cell function. We will map the locations of proteins within the cells and identify significant alterations in PD, much like using GPS technology to track the movements of city workers. By understanding these early molecular disruptions, we hope to identify early warning signs of PD and develop new treatments that target the root causes of the disease. This approach aims to not only provide better diagnostic tools but also to revolutionize the treatment of PD, potentially improving the quality of life for millions affected by this challenging condition.