Anup Kumar Srivastava, PhD, MSc

Children with Dravet syndrome (DS) often experience repeated seizures, developmental delays, learning difficulties, and sometimes sudden unexpected death from epilepsy (SUDEP). This disease is caused by a genetic mutation affecting the function of sodium channels in brain cells called neurons. When this channel does not work properly, neurons have a hard time regulating electrical impulses in the brain, leading to seizures. My research aims to engineer cells that, when delivered directly to the affected areas, will develop into functional neurons, thereby aiding in the restoration of normal brain function. However, there are significant challenges to overcome, including ensuring the survival of these cells, preventing their uncontrolled migration to other areas of the brain, and promoting their proper integration into the brain network. To address these challenges, we use a 3D-printed micron-sized cell delivery vehicle. This innovative technology allows us to place the cells precisely where they are needed, supporting their growth and local integration. Thus, this cell therapy approach holds promise for restoring brain function, reducing seizures, and preventing SUDEP in children with Dravet syndrome.