Research Supported by the PhRMA Foundation Funding

• Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion, Cancer Research, 70(17), September 2010, Carrie House, Charles Vaske, Arnold Schwartz, Vincent Obias, Bryan Frank, Truong Luu, Narine Sarvazyan, Rosalyn Irby, Robert Strausberg, Tim Hales, Joshua Stuart, and Norman Lee [link]


• "Sialidase enhances recovery from spinal cord contusion injury" Andrea Mountney a, Matthew R. Zahner b, Ileana Lorenzinia, Martin Oudega c,d,1, Lawrence P. Schrammb,e, and Ronald L. Schnaara,e,2 [link]


• High-precision high-coverage functional inference from integrated data sources.
  Linghu B, Snitkin ES, Holloway DT, Gustafson AM, Xia Y, DeLisi C.
  BMC Bioinformatics 9: 119 (2008). [link]


• The code within the code: MicroRNAs target coding regions. Forman JJ, Coller HA.
  Cell Cycle. 2010 Apr 13;9(8). [link]
  


• Detailing regulatory networks through large scale data integration.
  Huttenhower C, Mutungu KT, Indik N, Yang W, Schroeder M, Forman JJ, Troyanskaya OG, Coller HA.  Bioinformatics. 2009 Dec 15;25(24):3267-74.  [link]


• Discovering structural cis-regulatory elements by modeling the behaviors of mRNAs.
  Foat BC, Stormo GD.Mol Syst Biol. 2009;5:268. Epub 2009 Apr 28. [link]


• Rapid DNA Library Construction for Functional Genomic and Metagenomic Screening.
  Jonathan E. Schmitz,1,2 Anu Daniel,1 Mattias Collin,1, Raymond Schuch,1 and Vincent A. Fischetti1*  [link]


• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Heterogenous Particle Deaggregation and Its Implications for Therapeutic Aerosol Performance. Journal of Pharmaceutical Sciences (2010) 99 (8) March 15: 3442-3461.  Published online in Wiley InterScience. Abstract  [link]
  


• Schroeder, S.J. "Advances in RNA Structure Prediction from Sequence: New Tools for Generating Hypotheses about Viral RNA Structure-Function Relationships," J. Virol. 2009,  83, pp. 6326-6334.  [link]


• Schroeder, S.J., Turner, D.H. "Optical Melting Experiments of Nucleic Acid Thermodynamics," Methods Enz. 2009, 468, pp. 371-387.  [link]


• Mansour, H.M., Xu, Z., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Alternative Sugar Blends: 3. Trehalose Dihydrate and D-Mannitol Carriers. Journal of Pharmaceutical Sciences (2010) 99 (8) March12; 3430-3441.   Published online in Wiley InterScience.  [link]


• Xu, Z., Mansour, H.M., Mulder, T., McLean, R., Langridge, J., and Hickey, A.J. Dry Powder Aerosols Generated by Standardized Entrainment Tubes from Drug Blends with Lactose Monohydrate: 1. Albuterol Sulfate and Disodium Cromoglycate. Journal of Pharmaceutical Sciences (2010) 99 (8) March 2: 3398-3414.  [link]


• Understanding the Behavior of Amorphous Pharmaceutical Systems during Dissolution
• Author(s): Alonzo DE (Alonzo, David E.)2, Zhang GGZ (Zhang, Geoff G. Z.)1, Zhou DL (Zhou, Deliang)3, Gao Y (Gao, Yi)1, Taylor LS (Taylor, Lynne S.)2
• Source: PHARMACEUTICAL RESEARCH    Volume: 27    Issue: 4    Pages: 608-618    Published: APR 2010  [link]
  
  
• P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity
  Steven N Hart & Xiao-bo Zhong † University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA  [pdf]


• Identification of Structures within GABAA Receptor a Subunits That Regulate the Agonist Action of Pentobarbital. The Journal of Pharmacology and Experimental Therapeutics. 318:1094-1101, 2006. Brandon C. Drafts and Janet L. Fisher.[pdf]


• ModuleFinder: a tool for computational discovery of cis regulatory modules. Pacific Symposium on Biocomputing. 2005; p. 519-530. Philippakis AA, He FS, Bulyk ML.[Link]


• Nuclear Factor Kappa B is Constitutively Activated in Prostate Cancer In Vitro and is Increased in Prostatic Intra-epithelial Neoplasia and Adenocarcinoma of the Prostate. Clin Cancer Res. 2004 Aug 15; 10(16): 5501-7. Sweeney C, Shanmugam R, Li L, Bhat-Nakshatri P, Baldridge L, Zhang S, Gardner T, Kao C, Koch M, Nakshatri H, Cheng L. [Link]


• Practical approach for using Medicare data to estimate costs for cost-effectiveness analysis. Expert Rev. Pharmacoeconomics Outcomes Res. 5(2), 153-162 (2005). Tumeh, John W, Susan G Moore, Rachel Shapiro & Christopher R Flowers.


• Rapid analysis of the DNA binding specificities of transcription factors with DNA microarrays. Nature Genetics. 2004 Dec; 36(12):1331-1339. Epub 2004 Nov 14. Mukherjee S, Berger MF, Jona G, Wang XS, Muzzey D, Snyder M, Young RA, Bulyk ML.[Link]


• Reverse-engineering transcription control networks. Physics of Life Reviews 2, 65-88. Gardner, TS & J Faith. (2005)[Link]


• Structural Determinants of the Pharmacological Properties of the GABAA Receptor a6 Subunit. The Journal of Pharmacology and Experimental Therapeutics, 309:1108-1115, 2004. Brandon C. Drafts and Janet L. Fisher.


• Synaptic Activation of Metabotropic Glutamate Receptors Regulates Dendritic Outputs of Thalamic Interneurons. Neuron, Vol. 41, 611-623, February 19, 2004. Govindaiah and Charles L. Cox.


• The a1 and a6 subunit subtypes of the mammalian GABAA receptor confer distinct channel gating kinetics. The Journal of Physiology, 561:2 (2004) pp433-448. Janet L. Fisher.


• The Antiangiogenic Property of Docetaxel is Synergistic with rhuMAb-VEGF or 2-Methoxyestradiol but Antagonized by Endothelial Growth Factors. Cancer Res 2001; 61: 3369-3372. Sweeney, C., Miller, K.D., Sissons, S., Nozaki, S., Douglas K. Heilman, Jianzhao Shen , Sledge G.[Link]


• The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids. Pharmaceutical Research, Vol. 22, No. 5, May 2005. Laura M. Land, Ping Li, and Paul Michael Bummer.


• The Phase III Trial in the Era of Targeted Therapy: Unraveling the "Go or No Go" Decision. Journal of Clinical Oncology, Vol 21, No 19 (October 1), 2003: pp 3683-3695. Roberts, Thomas G. Jr, Thomas J. Lynch Jr, & Bruce A Chabner.


• The Pore Helix Dipole Has a Minor Role in Inward Rectifier Channel Function. Neuron, Vol. 47, 833-843, September 15, 2005. Daniel L. Minor, Jr.


• The Relationship Between Water Vapor Absorption and Desorption by Phospholipids and Bilayer Phase Transitions. Journal of Pharmaceutical Sciences, September 2006 - Published online in Wiley InterScience. Heidi M. Mansour, George Zografi.


• Trends in the Risks and Benefits to Patients With Cancer Participating in Phase 1 Clinical Trials. JAMA, November 3, 2004 - Vol 292, No. 17 (Reprinted). Roberts, Thomas G. Jr, MD, MSocSci, Bernardo H. Goulart, MD, Lee Squitieri, Sarah C. Stallings, PhD, Elkan F. Halpern, PhD, Bruce A. Chabner, MD, G. Scott Gazelle, MD, MPH, PhD, Stan N. Finkelstein, MD, Jeffrey W. Clark, MD.


• Vasoactive Intestinal Peptide Selectively Depolarizes Thalamic Relay Neurons and Attenuates Intrathalamic Rhythmic Activity. J Neurophysiol 90: 1224-1234, 2003. Sang-Hun Lee and Charles L. Cox.