Drug Discovery
Postdoctoral Fellowship

Drug discovery involves the innovative application and integration of multiple scientific disciplines to create efficacious, safe, and differentiated treatment options for patients. The PhRMA Foundation seeks to fund novel early-stage, drug discovery research with a clear potential for translation to humans. Proposals should focus on biological validation of potential drug targets, such as molecular targets, targetable pathways, or targetable systems.

Research areas could include, but are not limited to: 

• Cellular and Molecular Biology
• Design and Generation of Pharmacological Tools 
• In Vitro and/or In Vivo Pharmacology 
• Protein Biochemistry 
• Molecular Modelling 
• Structural Biology and Computational Structural Biology
• Biomedical Imaging (e.g., cellular)
• Single Cell Analysis (e.g., CRISPR screens) 
• Spatial Omics 
• Artificial Intelligence (AI) and Computational Approaches   

Projects that focus exclusively on single aspects such as identification of and development of assays for single targets, chemical probes, biomarkers, chemical library screening, or diagnostics will not be considered. Studies considered exploratory in nature should contain a rigor and reproducibility plan. 

Proposals that involve AI approaches (i.e., data-driven ML/DL) should clearly document and reference the methodology, explain the data curation process (sources, quality, quantity), and discuss the wet lab validation process. Expected pitfalls and alternative strategies should be described as well. 

Note: Please ensure you are applying to the correct PhRMA Foundation program. If your project does not align with the goals of the Drug Discovery Program, as outlined above, please review the PhRMA Foundation’s Drug Delivery and Translational Medicine programs to see whether your project fits into one of those programs. Contact the PhRMA Foundation (info@phrmafoundation.org) with your project description if you need further clarification. 

• Applicants (U.S. and non-U.S. citizens) must be based at a PhD and/or MS degree-granting accredited U.S. university.
• Applicants have a firm commitment from a research supervisor or sponsor at their university.
• Applicants must hold a PhD, PharmD, MD, or appropriate terminal research doctorate. If you do not hold one at the time of application submission, please state in your extended letter when you expect to receive it, as it must be received before funding can begin. Funding can begin as early as January 1, 2026, or as late as August 1, 2026.
• You are not eligible if your doctoral degree was granted before January 1, 2023.
• Applicants who have taken leave from their career (e.g., parenting of a child, childbirth, long-term care of a parent/spouse/child/dependent, personal health issues) that puts them outside of the eligibility time frame can reach out to PhRMA Foundation staff ahead of their LOI submission to determine their eligibility. The Foundation aims to be flexible and adjust these time frames if necessary and appropriate.
• Applicants currently funded on an institutional training grant (e.g., NIH TL1, T32, T90, or T35 awards or a nonprofit/professional society equivalent) may apply if they state they will forgo the institutional training slot if funded by a PhRMA Foundation postdoctoral award.
• Applicants are ineligible if they are the recipient of an NIH K99/R00 award or NIH-F award.
• An individual may not simultaneously hold another funding mechanism providing stipend support while the PhRMA Foundation postdoctoral fellowship is active. If necessary, the university may supplement the award to a level that is consistent with other postdoctoral fellowships it offers.
• Applicants who are applying for funds to support postdoctoral work in the laboratory where their graduate work was performed will be given lower preference. One of the objectives of this fellowship is to gain new skills, and therefore, an ideal candidate will be conducting their research in a new laboratory and not where their graduate work was performed.
• Only one postdoctoral applicant per lab may apply for this award. If multiple applicants apply, they will automatically be ineligible. Potential applicants and their mentor and/or lab managers should decide who should apply.
• The Foundation will not consider multiple applications for similar efforts on the same project. For instance, if a predoc, postdoc, and faculty member from the same lab are all submitting applications for proposed efforts on the same project, the efforts must be separate activities and not duplicative.

• The PhRMA Foundation Postdoctoral Fellowship in Drug Discovery provides $60,000 in stipend support per year for 12, 18, or 24 months.
• To receive funding beyond the first 12 months, awardees must provide the PhRMA Foundation with a satisfactory progress report upon completion of the first 10 months of funding.
• Funding is conditional upon the awardee’s continued employment with the university in the postdoctoral program, which will be assessed on a quarterly basis prior to payment. The awardee is required to notify the PhRMA Foundation if they leave the university.
• Payments will be made directly to the university on behalf of the awardee, with the understanding the university will administer the funds.
• This award is intended solely as a stipend and may not be used otherwise. PhRMA Foundation funds may not be used for tuition, fringe benefits, or indirect costs to the university.
• Funding may begin as early as January 1, 2026, or on the first day of any month thereafter, up to and including August 1, 2026.
• A financial report (separate from the 10-month progress report) will be required upon completion of the first 12 months of funding.
• A final progress report and financial report will be required within 60 days of the fellowship’s conclusion.
• Unspent funds are to be returned to the PhRMA Foundation.
• Any changes to the proposed project must be approved by the PhRMA Foundation.
• These funds are non-transferable.

Applicants must have primary responsibility for the writing and the preparation of the application, understanding the mentor will play a significant part in providing guidance to the applicant.

This is a two-step process. Step one is submitting a letter of intent (LOI) by April 15, 2025, at 12:00 p.m. (noon) ET. If your LOI is accepted, you will be notified by July 1, 2025, that you should proceed to the second step of submitting a full application, due August 28, 2025. 

To start a letter of intent, go to the ProposalCentral website at proposalcentral.com. If you are a new user of ProposalCentral, follow the link “Create an Account” and complete the registration process. If you are already a registered user, login with your username and password. If you have forgotten your password, click the “Forgot your Password?” link.

Once you are logged in, please click the “Professional Profile” tab at the top and complete steps 1-11 or update with your current information. Your name, degrees, position/title, academic rank, department, and address will be pulled from this page in ProposalCentral.

Step 1: Letter of Intent (LOI)

To submit an LOI, select the “Grant Opportunities” tab in ProposalCentral and a list of applications will be displayed. Find “PhRMA Foundation” and click the “Apply Now” link next to the Postdoctoral Fellowship in Drug Discovery Program.

Candidates are required to submit the following items at this stage: 

1. NIH Biosketch 

2. Project Abstract

3. 600-Word LOI

The LOI must describe the research project and its aims. It should be written by the applicant on U.S. letter-sized 8.5” x 11” pages with .5” margin and 11-point font. The first use of any abbreviation or acronym should be preceded by the full name or description. Citations and figures do not count toward the 600-word LOI limit. 

4. Research Impact Questions

Provide responses to the below questions using the template provided in Proposal Central: 

• Explain how your project fits into the PhRMA Foundation’s Drug Discovery Program.  
• What is the critical question you aim to address and how is your project an innovative way to address it?  
• What is the specific hypothesis/hypotheses you aim to test?  
• Explain how your project could advance drug development within a three-year time horizon.

LOIs are due by April 15, 2025, at 12:00 p.m. (noon) ET.

Step 2: Full Application (by invitation)

Applicants whose LOIs are selected by the review committee will be notified by July 1, 2025, and invited to submit a full application. Full application requirements will be sent via email and also posted here before the portal opens for full application submissions.

Full application deadline is August 28, 2025, at 12:00 p.m. (noon) EDT. Late submissions will not be accepted.

Award notification is December 15, 2025.